The European Rare Disease Models & Mechanisms Network (RDMM-Europe) has been established by Solve-RD – an EU-funded research project. The overall aim is to boost research in rare diseases, discover new disease-causing genes and obtain evidence for pathogenicity through functional validation.

For more information, visit the following website.

The European Rare Disease Models & Mechanisms Network (RDMM-Europe) has been established by Solve-RD – an EU-funded research project. The overall aim is to boost research in rare diseases, discover new disease-causing genes and obtain evidence for pathogenicity through functional validation.

For more information, visit the following website.

A call on research and innovation's actions will be launched on July 18, 2019. IMI projects aim at accelerating the medicines development process, generating new scientific insights, and developing resources for open use by the research community. The topics of this call are related to integrated research platforms, digital clinical trials, immune-mediated diseases, medicines safety, brain disorders, blockchain, antimicrobial resistance.

FInd more information on the following link.

The International Summer School on Rare Disease Registries and FAIRification of Data is a part of a series of training activities proposed by the European Joint Programme on Rare Diseases (EJP RD) which will take place at the Istituto Superiore di Sanità, Rome, Italy. The first module “Rare Disease Registries” starts on September 23 till September 25, 2019. The second module “FAIRification of data”, starts on September 26 till September 27, 2019.

Onlne registration deadline is June 20th, 2019.

Find more information on the following link.

The European Joint Programme on Rare Diseases (EJP RD), which is the successor of E-Rare launches the Joint Transnational Call 2019. The call will  open officially in December. This year projects should focus on accelerated diagnosis and/or exploration of disease progression and mechanisms of rare diseases. More info under www.ejprarediseases.org

Results of Joint Transnational Call 2016

Results of Joint Transnational Call 2016

In December 2015 E-rare launched the eigth E-Rare joint call (JTC 2016) for funding multilateral research projects on rare diseases on “Clinical research for new therapeutic uses of already existing molecules (repurposing) in rare diseases”. Fifteen countries joined this call: Austria, Belgium, Canada (including Québec), France, Germany, Hungary, Israel, Italy, Latvia, Poland, Portugal, Romania, Spain, Switzerland, and Turkey.

The aim of the call was to enable scientists in different countries to build an effective collaboration on a common interdisciplinary research project based on complementarities and sharing of expertise, with a clear translational research approach.

The process included a two-step submission and evaluation procedure.

In the first step a total of 30 eligible proposals were submitted. After careful examination by the Scientific Evaluation Committee (SEC), 20 proposals were selected for the second stage of evaluation. Each of the full proposals have been evaluated by at least two SEC members and two additional external experts during the first stage of evaluation and the reviews were sent to project coordinators in order to give them the opportunity of studying the assessments and commenting on experts' arguments and evaluations for the second stage of evaluation. Each of the full proposals and the answer to the reviews have been evaluated by at least three SEC members for the second stage of evaluation.

Following the second SEC evaluation and ranking of the best projects, 8 consortia with a foreseen budget of about 11.2 Mio € were selected for funding.

Selected projects:
DPem
Title: Dimethylfumarate for the treatment of bullous pemphigoid
Coordinator: Ralf Ludwig

HCQ4Surfdefect
Title: Hydroxychloroquine (HCQ) in pediatric ILD
Coordinator: Matthias Griese

NICOFA
Title: Nicotinamide for the treatment of Friedreich ataxia
Coordinator: Jörg Schulz

REALS
Title: Repurposed Enoxacin for the treatment of patients with Amyotrophic Lateral Sclerosis
Coordinator: Eran Hornstein

ReDox
Title: Repurposing doxycycline in the treatment of AL amyloidosis
Coordinator: Giovanni Palladini

ROCK-ALS
Title: Inhibition of Rho Kinase (ROCK) with Fasudil as disease-modifying treatment for ALS
Coordinator: Paul Lingor

ROPROP
Title: Propranolol for preemptive treatment of threshold retinopathy of prematurity
Coordinator: Christoph Bührer

TAMDMD
Title: Tamoxifen in Duchenne muscular dystrophy - a randomised placebo controlled phase 2 trial
Coordinator: Dirk Fischer

E-Rare 2012 - Created by Toussaint Biger