This section is dedicate to all types of European Initiatives that are related to the research on rare diseases.


Go to previous page


European Infrastructure for Phenotyping, Archiving and Distribution of Mouse Models

INFRAFRONTIER is the European Research Infrastructure for the development, phenotyping, archiving and distribution of mouse models of human diseases. INFRAFRONTIER enhances medical research by providing access to a unique collection of mouse models and research tools and associated data, and to state-of-the-art technologies for mouse model development and phenotype analyses. INFRAFRONTIER ensures open access to a sustainable mouse reference resource, thereby avoids duplication of efforts, contributes to a reduction of animal use, and underpins reproducibility in biomedical research.

Which services are provided?

-    Access to the European Mouse Mutant Archive (EMMA) resources
EMMA comprises over 4900 mutant mouse lines carrying targeted, transgenic, induced and other types of mutations. Numerous strains have been donated to EMMA by individual researchers. In addition, EMMA has built up major collections from large-scale projects and provides access to practical research tools.
Further details

-    Deposit mice into the EMMA repository
The European Mutant Mouse Archive (EMMA) welcomes submission of mutant mouse strains from all over the world, archives free of charge and facilitates global distribution.
Further details

-    Axenic Services (production of germ-free mouse lines)
If you need to study phenotypes in mouse strains independently of its microflora (for example to discriminate between autoimmunity and inflammatory immunopathologies or to understand the host-commensal interactions during tissue regeneration), INFRAFRONTIER offers as a service the generation of germ-free (axenic)
Further details

-    Mouse model development and phenotyping
INFRAFRONTIER offers the generation of new mouse mutant lines from existing gene-targeted ES cell clones and the first line phenotyping of a mutant line with appropriate control.
Further details

-    Training and consulting
INFRAFRONTIER and its partners offer a wide range of state-of-the-art training opportunities and consulting services like cryopreservation, phenotyping or European Medicines Training Network education on the whole life-cycle of medicines research.
Further details

Why to work with INFRAFRONTIER?
New gene mutations involved in the pathogenesis of rare diseases are discovered at increasing rates.  INFRAFRONTIER provides rare disease researchers with valuable research tools to better understand the biological function of these genes and to identify novel therapeutic pathways
How much does it cost?
There are different pricing models for accessing the INFRAFRONTIER resources and services; access to some of them is free-of-charge, others require the payment of a user fee to recover the cost of the service. Please consult the INFRAFRONTIER website for details.

Countries involved in INFRAFRONTIER:
INFRAFRONTIER GmbH Members : Czech Republic; Finland; France; Germany; Greece
INFRAFRONTIER Research Infrastructure : Austria; Belgium; Canada; Czech Republic; Denmark; Finland; France; Germany; Greece; Israel; Italy; Portugal; Spain; Sweden; United Kingdom, Canada
Observers : Ireland; Norway

INFRAFRONTIER headquarters contact point:


Find your national contact point by clicking on your country.

You have not found answers to your question, please send us your request and we will help you.

My request

E-Rare 2012 - Created by Toussaint Biger